Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice

作者：He Wenqian; Chen Chi Jene; Mullarkey Caitlin E; Hamilton Jennifer R; Wong Christine K; Leon Paul E; Uccellini Melissa B; Chromikova Veronika; Henry Carole; Hoffman Kevin W; Lim Jean K; Wilson Patrick C; Miller Matthew S; Krammer Florian; Palese Peter; Tan Gene S^*

来源：Nature Communications, 2017, 8(1): 846.

DOI：10.1038/s41467-017-00928-3

The aim of candidate universal influenza vaccines is to provide broad protection against influenza A and B viruses. Studies have demonstrated that broadly reactive antibodies require Fc-Fc gamma receptor interactions for optimal protection; however, the innate effector cells responsible for mediating this protection remain largely unknown. Here, we examine the roles of alveolar macrophages, natural killer cells, and neutrophils in antibody-mediated protection. We demonstrate that alveolar macrophages play a dominant role in conferring protection provided by both broadly neutralizing and non-neutralizing antibodies in mice. Our data also reveal the potential mechanisms by which alveolar macrophages mediate protection in vivo, namely antibody-induced inflammation and antibody-dependent cellular phagocytosis. This study highlights the importance of innate effector cells in establishing a broad-spectrum antiviral state, as well as providing a better understanding of how multiple arms of the immune system cooperate to achieve an optimal antiviral response following influenza virus infection or immunization.

• 出版日期2017-10-10