Different roles for M-1 and M-2 receptors within perirhinal cortex in object recognition and discrimination

作者：Bartko Susan J^*; Winters Boyer D; Saksida Lisa M; Bussey Timothy J

来源：Neurobiology of Learning and Memory, 2014, 110: 16-26.

DOI：10.1016/j.nlm.2014.01.002

• Medial temporal lobe
• Pirenzepine
• AF-DX 116
• Muscarinic toxin 7
• Muscarinic receptor
• Muscarinic subtypes

Recognition and discrimination of objects and individuals are critical cognitive faculties in both humans and non-human animals, and cholinergic transmission has been shown to be essential for both of these functions. In the present study we focused on the role of M-1 and M-2 muscarinic receptors in perirhinal cortex (PRh)-dependent object recognition and discrimination. The selective M-1 antagonists pirenzepine and the snake toxin MT-7, and a selective M-2 antagonist, AF-DX 116, were infused directly into PRh. Pre-sample infusions of both pirenzepine and AF-DX 116 significantly impaired object recognition memory in a delay-dependent manner. However, pirenzepine and MT-7, but not AF-DX 116, impaired oddity discrimination performance in a perceptual difficulty-dependent manner. The findings indicate distinct functions for M-1 and M-2 receptors in object recognition and discrimination.

• 出版日期2014-4