摘要

Unstrained carbon-carbon single bonds are ubiquitous in organic compounds, the cleavage of this bond is one of the most significant and challenging subject in organic chemistry. Oxidative cleavage of unstrained carbon-carbon single bond has become a great tendency, in particular, the transition metal-catalyzed oxidative cleavage reaction, which had made significant progress in recent years. Oxygen, as the most inexpensive and environmentally friendly oxidant, has been widely used in various organic reactions. This review is an overview of recent advances of unstrained carbon-carbon single bond cleavage with oxygen according to whether transition metal catalysis is needed.