Anxiety and depression propensities in patients with acute toxic liver injury

作者：Suh Jeong Ill^*; Sakong Jeong Kyu; Lee Kwan; Lee Yong Kook; Park Jeong Bae; Kim Dong Joon; Seo Yeon Seok; Lee Jae Dong; Ko Soon Young; Lee Byung Seok; Kim Seok Hyun; Kim Byung Seok; Kim Young Seok; Lee Heon Ju; Kim In Hee; Sohn Joo Hyun; Kim Tae Yeob; Ahn Byung Min

来源：World Journal of Gastroenterology, 2013, 19(47): 9069-9076.

DOI：10.3748/wjg.v19.i47.9069

• Liver injury
• Herb
• Toxic
• Anxiety
• Depression

AIM: To investigate anxiety and depression propensities in patients with toxic liver injury. %26lt;br%26gt;METHODS: The subjects were divided into three groups: a healthy control group (Group 1, n = 125), an acute non-toxic liver injury group (Group 2, n = 124), and a group with acute toxic liver injury group caused by non-commercial herbal preparations (Group 3, n = 126). These three groups were compared and evaluated through questionnaire surveys and using the Hospital Anxiety-Depression Scale (HADS), Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), and the hypochondriasis scale. %26lt;br%26gt;RESULTS: The HADS anxiety subscale was 4.9 +/- 2.7, 5.0 +/- 3.0 and 5.6 +/- 3.4, in Groups 1, 2, and 3, respectively. The HADS depression subscale in Group 3 showed the most significant score (5.2 +/- 3.2, 6.4 +/- 3.4 and 7.2 +/- 3.4 in Groups 1, 2, and 3, respectively) (P %26lt; 0.01 vs Group 1, P %26lt; 0.05 vs Group 2). The BAI and BDI in Group 3 showed the most significant score (7.0 +/- 6.3 and 6.9 +/- 6.9, 9.5 +/- 8.6 and 8.8 +/- 7.3, 10.7 +/- 7.2 and 11.6 +/- 8.5 in Groups 1, 2, and 3, respectively) (BAI: P %26lt; 0.01 vs Group 1, P %26lt; 0.05 vs Group 2) (BDI: P %26lt; 0.01 vs Group 1 and 2). Group 3 showed a significantly higher hypochondriasis score (8.2 +/- 6.0, 11.6 +/- 7.5 and 13.1 +/- 6.5 in Groups 1, 2, and 3, respectively) (P %26lt; 0.01 vs Group 1, P %26lt; 0.05 vs Group 2). %26lt;br%26gt;CONCLUSION: Psychological factors that present vulnerability to the temptation to use alternative medicines, such as herbs and plant preparations, are important for understanding toxic liver injury.

• 出版日期2013-12-21