Altered PLC beta-1 expression in the gerbil hippocampal complex following spontaneous seizure

作者：Lee Saet Byeol; Oh Yun Jung; Chung Jae Kwang; Jeong Ji Heon; Lee Sang Duk; Park Dae Kyoon; Park Kyung Ho; Ko Jeong Sik; Kim Duk Soo^*

来源：BMB Reports, 2011, 44(9): 566-571.

DOI：10.5483/BMBRep.2011.44.9.566

• Epilepsy
• Gerbil
• Hippocampus
• Immunohistochemistry
• Phospholipase C (PLC)

Although the phospholipase C (PLC)beta-1 isoform is associated with spontaneous seizure and distinctively expressed in the telencephalon, the distribution of PLC beta-1 expression in the epileptic gerbil hippocampus remains controversial. Therefore, we determined whether PLC beta-1 is associated with spontaneous seizure in an animal model of genetic epilepsy. In the present study, PLC beta-1 immunoreactivity was down-regulated in seizure-sensitive (SS) gerbils more than in seizure-resistant (SR) gerbils. The expression of PLC beta-1 within calretinin (CR)positive neurons was rarely detected within the dentate hilar region of SS gerbils. PLC beta-1 immunoreactivity in the hippocampus was significantly elevated as compared to that in pre-seizure SS gerbil 3 h post-ictal. These findings suggest that alterations in PLC beta-1 immunoreactivity in the SS gerbil hippocampus may be closely related to the epileptic state of the gerbil brain and transiently elevated PLC beta-1 protein levels following seizure episodes. Such alterations may be compensatory responses in the SS gerbil hippocampus. [BMB reports 2011; 44(9) : 566-571]

• 出版日期2011-9-30