An intelligent detection method for high-field asymmetric waveform ion mobility spectrometry

作者:Li, Yue; Yu, Jianwen; Ruan, Zhiming; Chen, Chilai*; Chen, Ran; Wang, Han; Liu, Youjiang; Wang, Xiaozhi; Li, Shan
来源:European Journal of Mass Spectrometry, 2018, 24(2): 191-195.
DOI:10.1177/1469066717743623

摘要

In conventional high-field asymmetric waveform ion mobility spectrometry signal acquisition, multi-cycle detection is time consuming and limits somewhat the technique's scope for rapid field detection. In this study, a novel intelligent detection approach has been developed in which a threshold was set on the relative error of alpha parameters, which can eliminate unnecessary time spent on detection. In this method, two full-spectrum scans were made in advance to obtain the estimated compensation voltage at different dispersion voltages, resulting in a narrowing down of the whole scan area to just the peak area(s) of interest. This intelligent detection method can reduce the detection time to 5-10% of that of the original full-spectrum scan in a single cycle.

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