Microbial Synthesis of Polyhydroxyalkanoate Copolymer Containing 3-Hydroxy-4-methylvalerate Unit: Recent Development and Perspective

作者：Saika Azusa^*; Tsuge Takeharu

来源：Kobunshi Ronbunshu, 2013, 70(10): 513-519.

• Polyhydroxyalkanoate
• 3H4MV Unit
• Fatty Acid Precursor
• Leucine Metabolism
• Leucine Analog Resistant Mutant

Polyhydroxyalkanoates (PHAs) are bio-based and biodegradable polyester synthesized by a wide variety of bacteria. To enhance the usability of PHA, we need to improve the material performance for wide-ranging applications and reduce the production cost during fermentation. We have developed biosynthesis methods for a novel PHA copolymer consisting of 3-hydroxybutyrate (3HB) and 3-hydroxy-4-methylvalerate (3H4MV) [P(3HB-co-3H4MV)], which shows improved long-term stability and processability than other known PHA copolymers. P(3HB-co-3H4MV) has the potential to broaden the use of PHA if it can be produced from inexpensive sugars with controlled 3H4MV fraction. This article summarizes recent advances in the study of P(3HB-co-3H4MV) biosynthesis.

• 出版日期2013