科研之友
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摘要
A continuous-flow protocol for Pd-catalyzed olefin cleavage by using molecular oxygen as the sole oxidant to give carbonyl compounds was explored. The developed flow protocol allowed the use of a low catalyst loading (0.1mol%), and decomposition of the active catalyst was prevented through stabilization by poly(ethylene glycol)-400 (PEG-400), which was present as a cosolvent. Radical scavengers inhibited the reaction, which indicated the involvement of a free-radical path in the reaction mechanism. The applicability of the continuous-flow protocol was demonstrated on several olefin substrates. The continuous-flow process enabled safe and scalable olefin cleavage.
- 出版日期2017-9-8
