A functional polymorphism in the promoter region of leptin gene increases susceptibility for non-small cell lung cancer

作者：Ribeiro R; Araujo AP; Coelho A; Catarino R; Pinto D; Araujo A; Calcada C; Lopes C; Medeiros R^*

来源：European Journal of Cancer, 2006, 42(8): 1188-1193.

DOI：10.1016/j.ejca.2006.02.004

• leptin
• lung cancer
• genetic polymorphism
• risk
• cigarette smoke

Leptin hormone and receptor have been associated to cancer development and were identified in lung tissue. In this study, a functional polymorphism in the S' flanking region of the leptin gene (LEP-2548G/A) was found to increase susceptibility for non-small cell lung cancer [odds ratio (OR), 1.97; 95% confidence interval (Cl), 1.13-3.43]. Age-adjusted logistic regression analysis in men indicated an association of AA genotype with adenocarcinoma (OR, 4.29; CI, 1.64-11.72) and squamous cell carcinoma (OR, 3.19; Cl, 1.26-8.13). Logistic regression analysis confirmed the AA genotype as an independent risk factor for lung cancer after adjustment for age and gender (OR, 2.57; CI, 1.34-4.92). The AA genotype was overrepresented only in patients with non-metastatic disease (OR, 1.86; Cl, 1.13-3.04). Kaplan-Meier analysis demonstrated an earlier age of onset for lung cancer in AA carriers (P = 0.023). Results suggest the existence of genetic susceptibility for lung cancer in carriers of this LEP functional polymorphism. Further studies are warranted to extend knowledge of leptin involvement in lung cancer.

• 出版日期2006-5