MR imaging features and staging of neuroendocrine carcinomas of the uterine cervix with pathological correlations

作者：Duan, Xiaohui; Ban, Xiaohua; Zhang, Xiang; Hu, Huijun; Li, Guozhao; Wang, Dongye; Wang, Charles Qian; Zhang, Fang; Shen, Jun^*

来源：European Radiology, 2016, 26(12): 4293-4302.

DOI：10.1007/s00330-016-4327-1

• Neuroendocrine tumours
• Cervical cancer
• Neoplasm staging
• Magnetic resonance imaging
• Diffusion-weighted imaging

To determine MR imaging features and staging accuracy of neuroendocrine carcinomas (NECs) of the uterine cervix with pathological correlations. @@@ Twenty-six patients with histologically proven NECs, 60 patients with squamous cell carcinomas (SCCs), and 30 patients with adenocarcinomas of the uterine cervix were included. The clinical data, pathological findings, and MRI findings were reviewed retrospectively. MRI features of cervical NECs, SCCs, and adenocarcinomas were compared, and MRI staging of cervical NECs was compared with the pathological staging. @@@ Cervical NECs showed a higher tendency toward a homogeneous signal intensity on T2-weighted imaging and a homogeneous enhancement pattern, as well as a lower ADC value of tumour and a higher incidence of lymphadenopathy, compared with SCCs and adenocarcinomas (P < 0.05). An ADC value cutoff of 0.90 x 10(-3) mm(2)/s was robust for differentiation between cervical NECs and other cervical cancers, with a sensitivity of 63.3 % and a specificity of 95 %. In 21 patients who underwent radical hysterectomy and lymphadenectomy, the overall accuracy of tumour staging by MR imaging was 85.7 % with reference to pathology staging. @@@ Homogeneous lesion texture and low ADC value are likely suggestive features of cervical NECs and MR imaging is reliable for the staging of cervical NECs. @@@ aEuro cent Cervical NECs show a tendency of lesion homogeneity and lymphadenopathy @@@ aEuro cent Low ADC values are found in cervical NECs @@@ aEuro cent MRI is an accurate imaging modality for the cervical NEC staging.

• 出版日期2016-12
• 单位中山大学; 华南肿瘤学国家重点实验室