Association between genome-wide association studies reported SNPs and pediatric-onset Crohn's disease in Canadian children

作者：Amre Devendra K^*; Mack David R; Morgan Kenneth; Israel David; Deslandres Colette; Seidman Ernest G; Lambrette Phlippe; Costea Irina; Krupoves Alfreda; Fegury Houda; Dong Jinsong; Xhu Zia; Grimard Guy; Levy Emile

来源：Human Genetics, 2010, 128(2): 131-135.

DOI：10.1007/s00439-010-0835-2

A recent pediatric-focused genome-wide association study has implicated three novel susceptibility loci for Crohn' disease (CD).We aimed to investigate whether the three recently reported and other previously reported genes/loci were also associated with CD in Canadian children. A case-control design was implemented at three pediatric gastroenterology clinics in Canada. Children < 19 years of age with a confirmed diagnosis of CD were recruited along with controls. Single nucleotide polymorphisms (SNPs) in 19 reported genes/loci were genotyped. Associations between individual SNPs and CD were examined. A total of 563 cases and 553 controls were studied. The mean (+/- SD) age of the cases was 12.3 (+/- 3.2) years. Most cases were male (56.0%), had ileo-colonic disease (L3 +/- A L4, 48.8%) and inflammatory behavior (B1 +/- A p, 87.9%) at diagnosis. Allelic association analysis (two-tailed) showed that 8 of the 19 targeted SNPs were significantly associated with overall susceptibility for CD. Associations with one additional SNP was borderline non-significant. Significantly associated SNPs included SNPs rs1250550 (p = 0.026) and rs8049439 (p = 0.04), recently reported to be specifically associated with pediatric-onset CD.Based on the results, we confirmed associations between two of the three novel pediatric-CD loci and other regions reported for associations with either pediatric and/or adult-onset CD.

• 出版日期2010-8
• 单位McGill