Asymmetric Synthesis of Ageliferin

作者:Wang Xiao; Ma Zhiqiang; Lu Jianming; Tan Xianghui; Chen Chuo*
来源:Journal of the American Chemical Society, 2011, 133(39): 15350-15353.
DOI:10.1021/ja207386q

摘要

We describe herein an asymmetric synthesis of ageliferin. A Mn(III)-mediated oxidative radical cyclization reaction was used as the key step to construct the core skeleton of this pyrrole-imidazole dimer. This approach resembles the biogenic [4 + 2] dimerization in an intramolecular fashion.

  • 出版日期2011-10-5