Study of Cognitive Functions and Cerebral Blood Flow in Elderly

作者：Hemeda Afaf A^*; Abdel Rahman Dalia R; Abdalla Mohamed Naguib; El Naggar Ahmed A; Riad Dina M

来源：Life Science Journal-Acta Zhengzhou University Overseas Edition, 2012, 9(4): 1704-1707.

• MMSE
• CBF
• Set test
• vascular dementia
• Alzheimer dementia

Background and Aim: Little information is available about cognitive functions and changes in cerebral blood flow in elderly people with or without cognitive dysfunction, despite the great influence of this problem on patient, family and society. Our study aimed at evaluating the cerebral blood flow (CBF) in elderly patient with cognitive dysfunction, either primary (Alzheimer Dementia), or secondary (vascular Dementia). Methods: assessment of the cognitive function and CBF of a group of 20 patients aged %26gt; 65 years old, 10 patients with vascular dementia while the other 10 patients with Alzheimer dementia and the results compared to a group of healthy volunteers. Results: all patients had significantly decreased Mini Mental State Examination (MMSE), Set test scores compared to that of healthy volunteers while there is significant difference regarding the Geriatric Depression Scale (GDS). Patients with vascular dementia had significantly diminished CBF compared to the healthy volunteers which doesn%26apos;t go for those with Alzheimer dementia. There is significant positive relationship between MMSE scores and CBF in patients with vascular dementia (r=0.77, p-value=0.009). Patients with vascular dementia had significantly high percent of hypertension and diabetes than do Alzheimer group. Conclusion: Brain ischemia was suggested to be the main factor responsible for decline of cognitive functions. The role of cerebral ischemia in Alzheimer dementia was insignificant. Cardiovascular risk factors are more related to vascular dementia. [Afaf A. Hemeda, Dalia R. Abdel-Rahman, Mohamed Naguib Abdalla, Ahmed A. El-Naggar and Dina M. Riad. Study of Cognitive Functions and Cerebral Blood Flow in Elderly. Life Sci J 2012;9(4):1704-1707] (ISSN:1097-8135). http://www.lifesciencesite.com. 261

• 出版日期2012