Reduction of Aryl Halides into Arenes with 2-Propanol Promoted by a Substoichiometric Amount of a tert-Butoxy Radical Source

作者：Ueno Ryota; Shimizu Takashi; Shirakawa Eiji^*

来源：Synlett, 2016, 27(5): 741-744.

DOI：10.1055/s-0035-1561342

• reduction
• radical chain mechanism
• anion radical
• ketyl
• tert-butoxy radical

Aryl halides are reduced into the corresponding arenes in high yields, using 2-propanol, cesium carbonate, and di-tert-butyl peroxide (or di-tert-butyl hyponitrite) as a reductant/solvent, a base, and a radical initiator, respectively. This simple system reduces a wide variety of aryl bromides, chlorides, and iodides through single-electron-transfer mechanism with high functional-group tolerance.

• 出版日期2016-3