科研之友
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摘要
In the current issue of Neurology (R), Shallcross et al.,(1) in a prospective observational study, compared cognitive and language skills of children born to women with epilepsy exposed in utero to levetiracetam (LEV, n = 53) or sodium valproate (VPA, n = 44), recruited from the UK Epilepsy Pregnancy Registry, and control children born to mothers without epilepsy or medication exposure during pregnancy (n = 133). Children were evaluated at the age of 36-54 months, building on previous findings at 24 months of age. The authors found no difference between LEV-exposed and control children. VPA-exposed children had lower scores on tests of gross motor skills, comprehension, and expressive language abilities than LEV-exposed children. The authors conclude that in utero exposure to VPA, but not LEV, is associated with neurodevelopmental deficits of motor and language abilities.
- 出版日期2014-1-21
