Association between air pollution and rhinitis incidence in two European cohorts

作者：Emilie Burte^*; Benedicte Leynaert; Roberto Bono; Bert Brunekreef; Jean Bousquet; Anne Elie Carsin; Kees De Hoogh; Bertil For**erg; Frederic Gormand; Joachim Heinrich; Jocelyne Just; Alessandro Marcon; Nino Kunzli; Mark Nieuwenhuijsen; Isabelle Pin; Morgane Stempfelet; Jordi Sunyer; Simona Villani; Valerie Siroux; Deborah Jarvis; Rachel Nadif; Benedicte Jacquemin

来源：Environment International, 2018, 115: 257-266.

DOI：10.1016/j.envint.2018.03.021

The association between air pollution and rhinitis is not well established.
Aim: The aim of this longitudinal analysis was to study the association between modeled air pollution at the subjects' home addresses and self-reported incidence of rhinitis.
Methods: We used data from 1533 adults from two multicentre cohorts' studies (EGEA and ECRHS). Rhinitis incidence was defined as reporting rhinitis at the second follow-up (2011 to 2013) but not at the first follow-up (2000 to 2007). Annual exposure to NO2, PM10 and PM2.5 at the participants' home addresses was estimated using land-use regression models developed by the ESCAPE project for the 2009-2010 period. Incidence rate ratios (IRR) were computed using Poisson regression. Pooled analysis, analyses by city and meta-regression testing for heterogeneity were carried out.
Results: No association between long-term air pollution exposure and incidence of rhinitis was found (adjusted IRR (aIRR) for an increase of 10 mu g center dot m(-3) of NO2: 1.00 [0.91-1.09], for an increase of 5 mu g center dot m(-3) of PM2.5: 0.88 [0.73-1.04]). Similar results were found in the two-pollutant model (aIRR for an increase of 10 mu g center dot m(-3) of NO2: 1.01 [0.87-1.17], for an increase of 5 mu g center dot m(-3) of PM2.5: 0.87 [0.68-1.08]). Results differed depending on the city, but no regional pattern emerged for any of the pollutants.
Conclusions: This study did not find any consistent evidence of an association between long-term air pollution and incident rhinitis.

• 出版日期2018-6