Are lipid disorders involved in the predominance of human T-lymphotropic virus-1 infections in women?

作者：de Carvalho Luciana Debortoli^*; Gadelha Sandra Rocha; Marin Lauro Juliano; Alvim Brito Melo Gustavo Eustaquio; Silveira Martins Camila Pacheco; da Fonseca Flavio Guimaraes; Barbosa Stancioli Edel Figueiredo

来源：Revista da Sociedade Brasileira de Medicina Tropical, 2015, 48(6): 759-761.

DOI：10.1590/0037-8682-0068-2015

• HTLV-1
• Lipid disorders and sex differences

Introduction: The human T-lymphotropic virus-1 (HTLV-1) is associated with chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), a chronic inflammatory disease. Disturbances in lipid metabolism are involved in inflammatory and demyelinating diseases. Methods: Plasma levels of triglycerides, total cholesterol, and fractions of HTLV-1-infected individuals of both sexes with different clinical progressions were determined. Results: Elevated levels of triglyceride and very low-density lipoproteins (VLDL) were exclusively detected in HTLV-1-infected women from asymptomatic and HAM/TSP groups compared with uninfected individuals (p = 0.02). Conclusions: Elevated triglyceride and VLDL levels in HTLV-1-infected women may be related to the predominance of HAM/TSP in women.

• 出版日期2015-12