Antiphospholipid syndrome and central nervous system

作者：Mayer Miroslav^*; Cerovec Mislav; Rados Marko; Cikes Nada

来源：Clinical Neurology and Neurosurgery, 2010, 112(7): 602-608.

DOI：10.1016/j.clineuro.2010.03.023

• Antiphospholipid syndrome
• Central nervous system
• Autoimmunity
• Thrombosis
• Demyelinization

Classification criteria, etiology, pathogenesis, major central nervous system (CNS) manifestations of the antiphospholipid syndrome (APS), as well as diagnostic and therapeutic approach are discussed in the article, supported by several MRI findings to illustrate differential complexity of selected topics. Close interplay of inflammation, autoimmunity, coagulation cascade, vasculature bed, neuron physiology and demyelinization in APS is elaborated. Cerebrovascular disease, multiple sclerosis-like syndrome, seizures, cognitive disfunction, headache and migraine, chorea and catastrophic antiphospholipid syndrome (CAPS) are discussed as the most prominent CNS manifestations of the APS.

• 出版日期2010-9