Reduced Expression of beta(2) Integrin Genes in Rat Peripheral Leukocytes by Inhibiting Postprandial Hyperglycemia

作者：Mochizuki Kazuki; Shimada Masaya; Tanaka Yutaro; Fukaya Nanae; Goda Toshinao^*

来源：Bioscience Biotechnology and Biochemistry, 2010, 74(12): 2470-2474.

DOI：10.1271/bbb.100554

• postprandial hyperglycemia
• alpha-glucosidase inhibitor
• miglitol
• beta(2)-integrin
• leukocytes

beta(2) integrins (CD11s/CD18) promote the attachment of leukocytes to vascular endothelial cells. We performed in this study sucrose loading to rats with moderate postprandial hyperglycemia with/without once-daily dosing of the alpha-glucosidase inhibitor, miglitol, for 4 days under 4-h fasting conditions. The streptozotocin (STZ)-treated rats showed moderate postprandial hyperglycemia on days 1 and 4. The gene expression was higher for CD11a with fasting and 3-h postprandial on day 1, and with fasting on day 4, for CD11b with fasting on day 1 and 3-h postprandial on day 4, and for CD18 with fasting on days 1 and 4 in peripheral leukocytes from the STZ-treated rats than in peripheral leukocytes from the saline-treated rats. Miglitol reduced postprandial hyperglycemia and the gene expression of CD11a with fasting and of CD11b 3-h postprandial on day 4. These results indicate that inhibiting postprandial hyperglycemia reduced the mRNA expression of beta(2) integrins in peripheral leukocytes of moderately postprandial hyperglycemic rats.

• 出版日期2010-12