An investigation on the anti-tumor properties of FSH33-53-Lytic

作者：Liu, Ping; Yang, Runlin; Pan, Donghui; Xu, Yuping; Zhu, Chen; Xu, Qing; Wang, Lizhen; Yan, Junjie; Li, Xiaotian^*; Yang, Min^*

来源：Journal of Radioanalytical and Nuclear Chemistry, 2016, 307(1): 89-97.

DOI：10.1007/s10967-015-4143-0

• FSHR
• Lytic
• Anti-tumor
• MicroPET imaging
• Drug evaluation

A new designed hybrid peptide FSH33-53-Lytic was synthesized and expected to combine the follicle stimulating hormone receptor (FSHR) targeting and tumor cell membranes disintegration. Through in vitro and vivo study, no significant enhancement on anti-tumor activity was shown compared with Lytic peptide only. We also prepared F-18-Al-NOTA-MAL-FSH33-53-Lytic and use microPET image to observe the FSHR targeting of FSH33-53-Lytic. No accumulation in the tumor may explain the failure of FSH33-53-Lytic on cancer therapy. In summary, microPET image can provide more accurate and visible information for screening new anti-tumor agents.

• 出版日期2016-1
• 单位江苏省原子医学研究所; 南京医科大学; 郑州大学