Preparation of 3-bromo-L-tyrosine and 3,5-dibromo-L-tyrosine

作者：Phillips Robert S^*; Bu**y Susan; Edenfield Leia; Wickware Kevin

来源：Amino Acids, 2013, 44(2): 529-532.

DOI：10.1007/s00726-012-1366-z

• Bromination
• Bromotyrosine
• Dibromotyrosine
• DMSO/HBr
• Tyrosine

l-Tyrosine is converted to 3-bromo-l-tyrosine in good yield by reaction with 1.2 equiv. of DMSO in HBr/AcOH, while reaction with 2.2 equiv. of DMSO under comparable conditions results in formation of 3,5-dibromo-l-tyrosine in good yield. This is the simplest, safest and most efficient method for the preparation of gram quantities of either 3-bromo-l-tyrosine or 3,5-dibromo-l-tyrosine.

• 出版日期2013-2