科研之友
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摘要
Bromodomains are protein domains that serve as "readers'' of acetylated lysine marks and mediate DNAtemplated processes. In this issue of Cell Chemical Biology, Olzscha et al. (2017) report that the CBP/p300 bromodomains mediate the formation of amyloid-like aggregates and that inhibitors specific to these bromodomains reduce the degree of protein aggregation and mitigate HDAC inhibitor-induced cytotoxicity.
- 出版日期2017-2-16
