Neuroprotective effect of paeonol on cognition deficits of diabetic encephalopathy in streptozotocin-induced diabetic rat

作者：Liu, Jiping; Feng, Liang; Ma, Dongying; Zhang, Minghua; Gu, Junfei; Wang, Shuyuan; Fu, Qiang; Song, Yu; Lan, Zhou; Qu, Rong; Ma, Shiping^*

来源：Neuroscience Letters, 2013, 549: 63-68.

DOI：10.1016/j.neulet.2013.06.002

• Paeonol
• Diabetic encephalopathy
• Cognition deficits
• Anti-apoptosis
• Neuropathological changes

Diabetic encephalopathy (DE) has been characterized by the impaired cognition and the abnormalities of neurochemistry and neurostructure. The study was conducted to evaluate the neuroprotective effect of paeonol on STZ-induced DE rats. Paeonol of 25, 50, 100 mg/kg (p.o.) could decrease the latency time and path length, and enhance significantly the spent time in the target quadrant and platform crossings in Morris water maze test. The treatment with paeonol could also increase significantly Na+-K+-ATP enzyme and ChAT activities, as well as decreasing significantly AchE activity in hippocampal tissue. Immunohistochemistry and TUNEL staining showed that paeonol could attenuate apoptosis of neurons and caspase 3 expression, improve two neurotrophic factors BDNF and IGF expressions, and also ameliorate A beta deposition in the hippocampus and cerebral cortex. In conclusion, the present study demonstrated diabetic rats treated with paeonol could ameliorate the cognition deficits. These findings indicated paeonol might act as a beneficial agent for the prevention and treatment of DE.

• 出版日期2013-8-9
• 单位中国药科大学; 陕西中医药大学; 江苏省中医药研究院; 南京中医药大学