Scattering Coefficients of Mice Organs Categorized Pathologically by Spectral Domain Optical Coherence Tomography

作者:Zhang, Q. Q.; Wu, X. J.; Wang, C.; Zhu, S. W.; Wang, Y. L.*; Gao, Bruce Z.; Yuan, X. -C.
来源:Biomed Research International, 2014, 2014: 471082.
DOI:10.1155/2014/471082

摘要

Differences in tissue density cause a variety of scattering coefficients. To quantify optical coherence tomography (OCT) images for diagnosis, the tissue's scattering coefficient is estimated by curve fitting the OCT signals to a confocal single backscattering mode. The results from a group of 30 mice show that the scattering coefficients of bone, skin, liver, brain, testis, and spleen can be categorized into three groups: a scattering coefficient between 1.947 and 2.134mm(-1): bone and skin; a scattering coefficient between 1.303 and 1.461mm(-1): liver and brain; a scattering coefficient between 0.523 and 0.634 mm(-1): testis and spleen. The results indicate that the scattering coefficient is tissue specific and could be used in tissue diagnosis.