Analysis of the Pseudouridimycin Biosynthetic Pathway Provides Insights into the Formation of C-nucleoside Antibiotics

作者：Sosio Margherita; Gaspari Eleonora; Iorio Marianna; Pessina Silvia; Medema Marnix H; Bernasconi Alice; Simone Matteo; Maffioli Sonia I; Ebright Richard H; Donadio Stefano

来源：Cell Chemical Biology, 2018, 25(5): 540-+.

DOI：10.1016/j.chembiol.2018.02.008

• C-nucleoside antibiotic
• PUM biosynthetic pathway
• PUM cluster
• PumJ
• RNAP inhibitor
• TruD-like
• Amide ligases
• Pseudouridimycin
• Pseudouridine synthase
• Specialized oxidoreductases and aminotransferases

Pseudouridimycin (PUM) is a selective nucleoside-analog inhibitor of bacterial RNA polymerase with activity against Gram-positive and Gram-negative bacteria. PUM, produced by Streptomyces sp. ID38640, consists of a formamidinylated, N-hydroxylated Gly-Gln dipeptide conjugated to 5'-aminopseudouridin...

• 出版日期2018-5-17