Design, synthesis and molecular docking studies of novel triazole antifungal compounds

作者：He, Qiu Qin; Li, Ke; Cao, Yong Bing; Dong, Huan Wen; Zhao, Li Hua; Liu, Chao Mei^*; Sheng, Chun Quan

来源：Chinese Chemical Letters, 2007, 18(6): 663-666.

DOI：10.1016/j.cclet.2007.04.025

• lanosterol 14 alpha-demethylase
• triazole
• tert-butyl
• antifungal activity
• fluconazole-resistant

Based on the active site of Candida albicans lanosterol 14 alpha-demethylase (CACYP51), novel triazole compounds structurally different from the current triazole drugs were designed and synthesized. In vitro antifungal activities showed that compounds 10, 11, 16 and 20 exhibited strong activities. In addition, compounds 10, 11 and 16 also displayed certain activities against fluconazole-resistant fungi.

• 出版日期2007-6
• 单位中国人民解放军第二军医大学