科研之友
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摘要
Objective: We investigated the clinical significance of ERp57 in the progression of cervical cancer. %26lt;br%26gt;Methods: mRNA and protein expression of ERp57 in cervical neoplasias were examined. %26lt;br%26gt;Results: ERp57 mRNA expression was significantly decreased in cervical cancers. Immunohistochemistry revealed that ERp57 expression in 123 cervical cancers was downregulated compared to cervical intraepithelial neoplasias or normal tissues (p%26lt;0.001). Low ERp57 expression was significantly associated with worse overall survival (HR = 12.19, p = 0.018). %26lt;br%26gt;Conclusions: Low ERp57 expression independently predicts a poor outcome for patients with cervical cancer, supporting the notion that ERp57 may be a promising novel cancer target.
- 出版日期2013-11
