An Ocular Commensal Protects against Corneal Infection by Driving an Interleukin-17 Response from Mucosal gamma delta T Cells

作者：St Leger Anthony J; Desai Jigar V; Drummond Rebecca A; Kugadas Abirami; Almaghrabi Fatimah; Silver Phyllis; Raychaudhuri Kumarkrishna; Gadjeva Mihaela; Iwakura Yoichiro; Lionakis Michail S; Caspi Rachel R

来源：Immunity, 2017, 47(1): 148-+.

DOI：10.1016/j.immuni.2017.06.014

Mucosal sites such as the intestine, oral cavity, nasopharynx, and vagina all have associated commensal flora. The surface of the eye is also a mucosal site, but proof of a living, resident ocular microbiome remains elusive. Here, we used a mouse model of ocular surface disease to reveal that commensals were present in the ocular mucosa and had functional immunological consequences. We isolated one such candidate commensal, Corynebacterium mastitidis, and showed that this organism elicited a commensal-specific interleukin-17 response from gamma delta T cells in the ocular mucosa that was central to local immunity. The commensal-specific response drove neutrophil recruitment and the release of antimicrobials into the tears and protected the eye from pathogenic Candida albicans or Pseudomonas aeruginosa infection. Our findings provide direct evidence that a resident commensal microbiome exists on the ocular surface and identify the cellular mechanisms underlying its effects on ocular immune homeostasis and host defense.

• 出版日期2017-7-18
• 单位河北医科大学