A facile synthesis of diverse 5-arylated triazoles via a Cu-catalyzed oxidative interrupted click reaction with arylboronic acids in air

作者：Yu, Xiaoxia; Xu, Jian; Zhou, Yao; Song, Qiuling^*

来源：Organic Chemistry Frontiers, 2018, 5(16): 2463-2467.

DOI：10.1039/c8qo00590g

• AZIDE-ALKYNE CYCLOADDITION
• FULLY-SUBSTITUTED 1,2,3-TRIAZOLES
• ONE-POT SYNTHESIS
• REGIOSELECTIVE SYNTHESIS
• DIRECT ARYLATION
• 1,4-DISUBSTITUTED 1,2,3-TRIAZOLES
• CHEMISTRY
• MECHANISM
• COPPER(I)
• MILD

We herein disclose a Cu-catalyzed synthesis of 5-arylsubstituted 1,2,3-triazoles via an oxidative interrupted click reaction, using air as the sole terminal oxidant. The current protocol provides a novel method for the one-step construction of fully substituted triazoles in good yields under mild conditions, in which arylboronic acids are employed as aromatic sources to interrupt the cuprate-triazole intermediate for the first time.

• 出版日期2018-8-21
• 单位华侨大学