A Spatial Ecology Study of Keshan Disease and Hair Selenium

作者：Zhang, Xiao; Wang, Tong^*; Li, Shie; Ye, Chao; Hou, Jie; Li, Qi; Liang, Hong; Zhou, Huihui; Guo, Zhongying; Han, Xiaomin; Wang, Zhe; Wu, Huan; Gao, Xiangzhi; Xu, Chunyan; Zhen, Rongxia; Chen, Xiangli; Duan, Yani; Wang, Yanan; Han, Shan

来源：Biological Trace Element Research, 2019, 189(2): 370-378.

DOI：10.1007/s12011-018-1495-7

• Keshan disease
• Hair selenium
• Ecological study
• Spatial epidemiology
• Elimination assessment
• Precise prevention

Few spatial ecological studies on hair selenium (Se) and Keshan disease (KD) have been reported. To investigate the relationships of hair Se with KD and economic indicators and to visualize the evidence for KD precise prevention. An ecological study design was employed. The levels of hair Se of 636 adult men (18years old) living in rural, general cities and developed cities in 15 KD endemic provinces and 11 KD non-endemic provinces in mainland China were measured using hydride generation atomic fluorescence spectrometry. Spatial description and spatial analysis of hair Se were conducted. The subjects were adults aged. The hair Se level of the residents of KD endemic areas was 0.30mg/kg, statistically significantly lower than that of non-endemic areas 0.34mg/kg (Mann-Whitney U test, p=0.007). The hair Se level of the 636 people was 0.33mg/kg. The hair Se levels of the residents of the developed cities, general cities, and rural were 0.35mg/kg, 0.33mg/kg, and 0.32mg/kg, respectively, with statistical significance (Kruskal-Wallis H test, P=0.032). Spatial regression analysis showed that the spatial distribution of hair Se was positively correlated with per capita GDP. Selenium deficiency may still exist among residents living in the KD endemic areas. The results of spatial description and analysis of hair Se provided visualized evidence for targeting key provinces for precise prevention of Keshan disease, including assessment of KD elimination. The hair Se level of the mainland Chinese males was probably between 0.31 and 0.33g/g in 2015.

• 出版日期2019-6
• 单位塔里木大学; 中国人民解放军总医院; 哈尔滨医科大学; 齐齐哈尔医学院; 杭州市疾病预防控制中心