Vitamin D deficiency and placental calcification in low-risk obstetric population: are they related?

作者：Findik Rahime Bedir^*; Ersoy Ali Ozgur; Fidanci Vildan; Tasci Yasemin; Helvacioglu Yeksin; Karakaya Jale

来源：Journal of Maternal-Fetal and Neonatal Medicine, 2016, 29(19): 3189-3192.

DOI：10.3109/14767058.2015.1118043

• Calcium
• placental calcification
• pregnancy
• vitamin D

Objective: We aimed to evaluate the relationship between placental calcification and maternal and cord blood 25-hydroxyvitamin-D-3 [25(OH)D] and calcium concentrations in low-risk obstetric population at term and their consequences.
Methods: Sixty non-complicated pregnant women at term admitted to maternity clinic were included in this prospective case-control study and classified into one of two groups according to grade of placental calcification by defined the Grannum classification: Group 1 (n = 30), with Grade 3 placenta and Group 2 (n = 30), the control group, no placental calcification noted. Baseline characteristics, maternal serum and umbilical cord 25(OH) D and calcium levels were compared between groups.
Results: The mean age of subjects was 26.4 +/- 5.7 years. The mean serum 25(OH)D concentration of women (n = 60) was 9.3 +/- 3.4 (range 5.59-15.48) ng/mL. The prevalence of vitamin D deficiency [25(OH)D<20 ng/mL] was 100%. Maternal serum and cord blood calcium levels were significantly higher in Group 1 (p = 0.036; p = 0.037, respectively). In Group 2, maternal serum and cord blood 25(OH)D levels were higher than Group 1 (11.35 +/- 6.54 and 10.22 +/- 3.59 versus 9.6 +/- 4.2 and 9.07 +/- 2.43 ng/mL); but the difference is not statistically significant.
Conclusions: Higher maternal calcium and lower 25(OH)D levels detected in patients with Grade 3 placental calcification indicated the importance of placenta on vitamin D regulation.

• 出版日期2016