Diastereoselective synthesis of a core fragment of ritonavir and lopinavir

作者：Roy Arnab; Reddy Lekkala Amarnath; Dwivedi Namrata; Naram Jyothirmayi; Swapna Rodda; Malakondaiah Golla China; Ravikumar Mylavarpu; Bhalerao Dinesh; Pratap Taduri Bhanu; Reddy Padi Pratap; Bhattacharya Apurba; Bandichhor Rakeshwar^*

来源：Tetrahedron Letters, 2011, 52(51): 6968-6970.

DOI：10.1016/j.tetlet.2011.10.087

• Asymmetric nitroaldol reaction
• Henry reaction
• Diastereoselective synthesis
• HIV protease inhibitors
• beta-Amino aldehyde

A novel approach to the synthesis of Boc-core, a key starting material for ritonavir and lopinavir involving an unprecedented diastereoselective nitroaldol reaction on beta-amino aldehyde is disclosed.

• 出版日期2011-12-21