A novel pH-sensitive liposome to trigger delivery of afatinib to cancer cells: Impact on lung cancer therapy

作者：Almurshedi Alanood S; Radwan Mahasen; Omar Samiah; Alaiya Ayodele A; Badran Mohamed M; Elsaghire Hanaa; Saleem Imran Y; Hutcheon Gillian A

来源：Journal of Molecular Liquids, 2018, 259: 154-166.

DOI：10.1016/j.molliq.2018.03.024

• Afatinib
• PH-sensitive liposomes
• In vitro release
• Anticancer activity
• Lung cancers

Abstract(#br)A novel drug delivery systems based on cationic (CL) and pH-sensitive liposomes (PSL) for tyrosine kinase inhibitor afatinib (AFT) were developed to enhance tumor-targetability against NSCLC cells and therapeutic effect. Optimal lipid to drug ratio was selected to prepare AFT-loaded PSL...

• 出版日期2018-6-1