A network map of Interleukin-10 signaling pathway

作者：Verma Renu; Balakrishnan Lavanya; Sharma Kusum; Khan Aafaque Ahmad; Advani Jayshree; Gowda Harsha; Tripathy Srikanth Prasad; Suar Mrutyunjay; Pandey Akhilesh; Gandotra Sheetal; Prasad T S Keshava; Shankar Subramanian^*

来源：Journal of Cell Communication and Signaling, 2016, 10(1): 61-67.

DOI：10.1007/s12079-015-0302-x

• Co-stimulatory molecules
• Interferon-gamma (IFN-gamma)
• Lipopolysaccharides
• Pro-inflammatory cytokines
• Protein-protein interactions
• Translocation
• NetSlim
• Systems biology markup language

Interleukin-10 (IL-10) is an anti-inflammatory cytokine with important immunoregulatory functions. It is primarily secreted by antigen-presenting cells such as activated T-cells, monocytes, B-cells and macrophages. In biologically functional form, it exists as a homodimer that binds to tetrameric heterodimer IL-10 receptor and induces downstream signaling. IL-10 is associated with survival, proliferation and anti-apoptotic activities of various cancers such as Burkitt lymphoma, non-Hodgkins lymphoma and non-small scell lung cancer. In addition, it plays a central role in survival and persistence of intracellular pathogens such as Leishmania donovani, Mycobacterium tuberculosis and Trypanosoma cruzi inside the host. The signaling mechanisms of IL-10 cytokine are not well explored and a well annotated pathway map has been lacking. To this end, we developed a pathway resource by manually annotating the IL-10 induced signaling molecules derived from literature. The reactions were categorized under molecular associations, activation/inhibition, catalysis, transport and gene regulation. In all, 37 molecules and 76 reactions were annotated. The IL-10 signaling pathway can be freely accessed through NetPath, a resource of signal transduction pathways previously developed by our group.

• 出版日期2016-3
• 单位河北医科大学