Multi-level Assessment Cerebrospinal Fluid Flow in Patients with Chiari I Malformation

作者：Bogomyakova Olga^*; Stankevich Yu; Shraibman L; Tulupov A

来源：Applied Magnetic Resonance, 2014, 45(8): 785-796.

DOI：10.1007/s00723-014-0558-y

The purpose of this study is to characterize the cerebrospinal fluid (CSF) flow throughout the cardiac cycle in the conditions of Chiari I at intracranial and cervical levels. Magnetic resonance imaging studies were examined with phase-contrast magnetic resonance imaging retrospectively cardiac triggered (Quantitative Flow technique). 60 healthy volunteers (control group) and 12 patients with the anomaly of Chiari I (patient's group) were investigated. Mean velocity, mean flux and peak velocity values of CSF flow at the five levels (the Sylvian aqueduct, the fourth ventricle, the Magendie's foramen, subarachnoid space of the foramen occipital magnum and the cervical level) were defined. Analysis of differences between respective mean values of CSF flow has shown that CSF flow characteristics have the highest values in the Sylvian aqueduct and on the cervical level in both groups. Our findings show that mean velocity and mean flux of antegrade (from head to feet) flow have significantly higher values in comparison with the retrograde flow (from feet to head) through investigated structures, respectively (p < 0.01). Our findings show the importance of multi-level cerebrospinal fluid flow assessment and allow investigating this system as a single whole, with their relationships and interaction laws.

• 出版日期2014-8