No Overt Deficits in Aged Tau-Deficient C57Bl/6.Mapt(tm1(EGFP)Kit) GFP Knockin Mice

作者：van Hummel Annika; Bi Mian; Ippati Stefania; van der Hoven Julia; Volkerling Alexander; Lee Wei S; Tan Daniel C S; Bongers Andre; Ittner Arne; Ke Yazi D; Ittner Lars M^*

来源：PLos One, 2016, 11(10): e0163236.

DOI：10.1371/journal.pone.0163236

Several mouse lines with knockout of the tau-encoding MAPT gene have been reported in the past; they received recent attention due to reports that tau reduction prevented A beta-induced deficits in mouse models of Alzheimer's disease. However, the effects of long-term depletion of tau in vivo remained controversial. Here, we used the tau-deficient GFP knockin line Mapt(tm1(EGFP)kit) on a pure C57Bl/6 background and subjected a large cohort of males and females to a range of motor, memory and behavior tests and imaging analysis, at the advanced age of over 16 months. Neither heterozygous nor homozygous Mapt(tm1(EGFP)kit) mice presented with deficits or abnormalities compared to wild-type litter-mates. Differences to reports using other tau knockout models may be due to different genetic backgrounds, respective gene targeting strategies or other confounding factors, such as nutrition. To this end, we report no functional or morphological deficits upon tau reduction or depletion in aged mice.

• 出版日期2016-10-13