Application of a modified Mosher's method for the determination of enantiomeric ratio and absolute configuration at C-3 of chiral 1,3-dihydroxy ketones

作者：Galman James L; Hailes Helen C^*

来源：Tetrahedron: Asymmetry , 2009, 20(15): 1828-1831.

DOI：10.1016/j.tetasy.2009.07.023

The enantiomeric ratio and absolute configuration of products of the transketolase reaction are typically determined by comparison of the specific rotation or derivatisation and HPLC or GC. A Mosher's ester method has been developed via ester formation at the primary alcohol C-1 which can be used to determine the stereoselectivity of the reaction, as well as the absolute configuration of the product at C-3.

• 出版日期2009-8-12