Age-related accumulation of Reelin in amyloid-like deposits

作者：Knuesel Irene^*; Nyffeler Myriel; Mormede Cecile; Muhia Mary; Meyer Urs; Pietropaolo Susanna; Yee Benjamin K; Pryce Christopher R; LaFerla Frank M; Marighetto Aline; Feldon Joram

来源：Neurobiology of Aging, 2009, 30(5): 697-716.

DOI：10.1016/j.neurobiolaging.2007.08.011

• Mus musculus
• Rattus norvegicus
• Callithrix jacchus
• Hippocampus
• Stratum lacunosum-moleculare
• Entorhinal cortex
• Piriform cortex
• Episodic-like memory
• Radial arm maze
• GABAergic interneurons
• PolyIC
• Neuroinflammation
• 3xTg-AD mice
• SynGAP
• GFAP
• Dab1
• F4/80
• Immunohistochemistry
• Alzheimer's disease

Accumulating evidence suggest that alterations in Reelin-mediated signaling may contribute to neuronal dysfunction associated with Alzheimer's disease (AD), the most common form of senile dementia. However, limited information is available on the effect of age, the major risk factor of AD, on Reelin expression. Here, we report that normal aging in rodents and primates is accompanied by accumulation of Reelin-enriched proteinous aggregates in the hippocampal formation that are related to the loss of Reelin-expressing neurons. Both phenomena are associated with age-related memory impairments in wild-type mice. We provide evidence that normal aging involves loss of Reelin neurons, reduced production and elimination of the extracellular deposits, whereas a prenatal immune challenge or the expression of AD-causing gene products, result in earlier, higher, and more persistent levels of Reelin-positive deposits. These aggregates co-localize with non-fibrillary amyloid-plaques, potentially representing oligomeric A beta species. Our findings suggest that elevated Reelin plaque load creates a precursor condition for senile plaque deposition and may represent a critical risk factor for sporadic AD.

• 出版日期2009-5