Anti-inflammatory intravenous immunoglobulin (IVIg) suppresses homeostatic proliferation of B cells

作者：Hori Ayane; Fujimura Takashi^*; Kawamoto Seiji^*

来源：Cytotechnology, 2018, 70(3): 921-927.

DOI：10.1007/s10616-017-0176-2

• Aggregation
• B cells
• Homeostatic proliferation
• Intravenous immunoglobulin (IVIg)

An intravenous injection of plasma-derived immunoglobulins is used for the treatment of severe infectious and autoimmune disorders. Despite of its clinical efficacy, precise mechanisms by which intravenous immunoglobulin (IVIg) suppresses proinflammatory immune response are still enigmatic. Here, we provide in vitro evidence that IVIg inhibits homeostatic proliferation of B cells accompanied by induction of their cell aggregation. The IVIg-driven suppression of B cell proliferation and induction of cell aggregation are both unaffected by treatment with a neutralizing antibody against low-affinity Fc receptors for IgG (CD16/Fc gamma RIII and CD32/Fc gamma RII), known cell surface ligands for IVIg. Our observations propose a new immunosuppressive action of IVIg, which directly acts on steady-state B cells to suppress their homeostatic expansion.

• 出版日期2018-6