Protective Effect of Cimicifuga heracleifolia Ethanol Extract and Its Constituents against Gastric Injury

作者：Kim Mijeong; Hwang In Young; Lee Je Hyuk; Son Kun Ho; Jeong Choon Sik; Jung Joohee^*

来源：Journal of Health Science, 2011, 57(3): 289-292.

• Cimicifuga heracleifolia
• anti-helicobacter pylori
• gastric protection
• ferulic acid
• caffeic acid

Cimicifuga heracleifolia (CH) ethanol extract and its constituents such as ferulic acid, caffeic acid, 24-epi-7,8-didehydrocimigenol-3-xyloside, and 23-O-acetylshengmanol 3-xyloside were investigated for their abilities to prevent gastric injury. To elucidate their gastric-protective effects, we assessed 1,1-diphenyl-2-picrylhydrazyl radical-radical scavenging activity and inhibition of Helicobacter pylori (H. pylori) and gastric cancer cells. Ferulic acid and caffeic acid exhibited higher free radical scavenging activity than other constituents and inhibited the colonization of H. pylori effectively. Furthermore, 24-epi-7,8-didehydrocimigenol-3-xyloside and 23-O-acetylshengmanol-3-xyloside showed cytotoxicity in gastric cancer cells (SNU638 and AGS cells). These results suggest the novel activities of CH ethanol extract and its constituents. CH ethanol extract and its constituents could be utilized for the treatment and/or prevention of gastric injury.

• 出版日期2011-6