A Proof-of-Concept Study of the Efficacy of Systemically Administered Polymyxins in Mouse Burn Wound Infection Caused by Multidrug-Resistant Gram-Negative Pathogens

作者：Lin Yu Wei; Chen Ke; Wang Jiping; Velkov Tony; Zhou Qi Tony; Li Jian^*

来源：Antimicrobial Agents and Chemotherapy, 2018, 62(5): e02527-17.

DOI：10.1128/AAC.02527-17

• polymyxins
• thermal injury
• multidrug resistance
• Pseudomonas aeruginosa
• Acinetobacter baumannii
• Klebsiella pneumoniae

The efficacy of subcutaneously administered polymyxins against burn wound infections caused by Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae was examined in a murine infection model. Subcutaneously administered colistin and polymyxin B (30 mg/kg thrice daily) achieved a >= 2-log(10) reduction in the bacterial load for P. aeruginosa and A. baumannii infections, whereas wound infections by K. pneumoniae were less responsive (<1-log(10) reduction). This study highlights the potential therapeutic benefits of parenteral polymyxins for treating burn wound infections.

• 出版日期2018-5