科研之友
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摘要
A novel method was developed for the selective oxidation of alpha-monosubstituted malononitrile and cyanoacetic ester derivatives at the alpha-position based on transition-metal-catalyzed reaction (Cu, Fe, Mn, Co) with tert-butyl hydroperoxide giving unsymmetrical peroxides in 63-94% yields. The method is facile, does not require large excesses of reagents, and is amenable to gram-scale synthesis.
- 出版日期2011-7
