Active Metabolites from Endolichenic Fungus Talaromyces sp.

作者:Yuan, Wei-Hua*; Teng, Meng-Ting; Sun, Shan-Shan; Ma, Lin; Yuan, Bo; Ren, Qiang*; Zhang, Peng*
来源:Chemistry and Biodiversity, 2018, 15(11): e1800371.
DOI:10.1002/cbdv.201800371

摘要

The active metabolites investigation of Talaromyces sp. (strain No. MH551540) associated with Xanthoparmelia angustiphylla afforded one new delta-lactone, talaromycin A (1), together with six known compounds, clearanol A (2), 6-methylbiphenyl-3,3 ',4,5 '-tetraol (3), desmethylaltenusin (4), ergone (5), ergosterol (6), and palmitic acid (7). The structures of these compounds were elucidated by a combination of spectroscopic-data interpretation and single-crystal X-ray diffraction analysis. The cytotoxicities of 1-7 and the antioxidant activities of 3 and 4 were also evaluated.