Activation and repression in the nervous system

作者:Goodman RH*; Mandel G
来源:Current Opinion in Neurobiology, 1998, 8(3): 413-417.
DOI:10.1016/S0959-4388(98)80069-X

摘要

The mechanisms underlying transcriptional activation and repression have become much clearer. Recent evidence suggests that transcription factors that do not bind DNA directly, the co-activators and co-repressors, mediate a large number of cell signaling events. Their association with histone acetylases, to mediate activation, or deacetylases, to mediate repression, provide a model for explaining how gene expression is regulated.

  • 出版日期1998-6