Advances in Sudden Death Prevention: The Emerging Role of a Fully Subcutaneous Defibrillator

作者：Majithia Arjun^*; Estes N A Mark III; Weinstock Jonathan

来源：American Journal of Medicine, 2014, 127(3): 188-194.

DOI：10.1016/j.amjmed.2013.10.018

• Defibrillator
• Implantable cardioverter defibrillator
• Subcutaneous defibrillator
• Sudden cardiac death

Randomized clinical trials support the use of implantable defibrillators for mortality reduction in specific populations at high risk for sudden cardiac death. Conventional transvenous defibrillator systems are limited by implantation-associated complications, infection, and lead failure, which may lead to delivery of inappropriate shocks and diminish survival. The development of a fully subcutaneous defibrillator may represent a valuable addition to therapies targeted at sudden death prevention. The PubMed database was searched to identify all clinical reports of the subcutaneous defibrillator from 2000 to the present. We reviewed all case series, cohort analyses, and randomized trials evaluating the safety and efficacy of subcutaneous defibrillators. The subcutaneous defibrillator is a feasible development in sudden cardiac death therapy and may be useful particularly to extend defibrillator therapy to patients with complicated anatomy, limited vascular access, and congenital disease. The subcutaneous defibrillator should not be considered in patients with an indication for cardiac pacing or who have ventricular tachycardia responsive to antitachycardia pacing. Further investigation is needed to compare long-term, head-to-head performance of subcutaneous defibrillators and conventional transvenous defibrillator systems. Published by Elsevier Inc.

• 出版日期2014-3