New mathematical derivations for calculation of ATP yield due to the complete oxidation of different types of fatty acids

作者：Reddy Banda Venkat; Prasad Bommena Rajendra; Sinha Sukesh Narayan^*; Ahmed Noor

来源：Indian Journal of Biochemistry & Biophysics, 2014, 51(1): 52-57.

• Fatty acids
• Respiratory chain
• beta-Oxidation

During the complete oxidation of fatty acids, the electrons removed from fatty acids in different forms (FADH(2) and NADH(2)) pass through the respiratory chain, driving the ATP synthesis. Generally, the ATP yield due to the complete oxidation of fatty acids is calculated by sum total the ATPs obtained due to the oxidation of FADH(2) and NADH(2) due to lack of any particular method. This calculation is simple for saturated even numbered fatty acids, but in the case of saturated and unsaturated odd numbered fatty acids the calculation of ATP yield is difficult and needs mathematical calculations due to some changes in their beta-oxidation pathway when compared to the pathway of saturated even numbered fatty acids. These calculations are made simple by our derivations and following formulae where we require only number of carbon atoms and double bonds present in a fatty acid. Our method is superior and easier in comparison to long mathematical calculations that are in the practice.

• 出版日期2014-2