pfk13-Independent Treatment Failure in Four Imported Cases of Plasmodium falciparum Malaria Treated with Artemether-Lumefantrine in the United Kingdom

作者：Sutherland Colin J; Lansdell Paul; Sanders Mandy; Muwanguzi Julian; van Schalkwyk Donelly A; Kaur Harparkash; Nolder Debbie; Tucker Julie; Bennett Hayley M; Otto Thomas D; Berriman Matthew; Patel Trupti A; Lynn Roderick; Gkrania Klotsas Effrossyni; Chiodini Peter L

来源：Antimicrobial Agents and Chemotherapy, 2017, 61(3): e02382-16.

DOI：10.1128/AAC.02382-16

• imported malaria
• treatment failure
• parasite genotyping
• antimalarial agents
• drug resistance mechanisms

We present case histories of four patients treated with artemether-lumefantrine for falciparum malaria in UK hospitals in 2015 to 2016. Each subsequently presented with recurrent symptoms and Plasmodium falciparum parasitemia within 6 weeks of treatment with no intervening travel to countries where malaria is endemic. Parasite isolates, all of African origin, harbored variants at some candidate resistance loci. No evidence of pfk13-mediated artemisinin resistance was found. Vigilance for signs of unsatisfactory antimalarial efficacy among imported cases of malaria is recommended.

• 出版日期2017-3