Assessment of the sedative effects of buprenorphine administered with 10 mu g/kg detomidine in horses

作者：Love E J^*; Taylor P M; Murrell J; Whay H R; Waterman Pearson A E

来源：The Veterinary Record, 2011, 168(14): 378-U50.

DOI：10.1136/vr.c7288

The aim of this randomised, observer-blinded, crossover study was to compare the effects of six treatments, administered intravenously to six horses: saline and saline (S/S); detomidine and saline (D/S); detomidine and 5 mu g/kg buprenorphine (D/B5); detomidine and 7.5 mu g/kg buprenorphine (D/B7.5); detomidine and 10 mu g/kg buprenorphine (D/B10); and detomidine and 25 mu g/kg butorphanol (D/BUT). The detomidine dose was 10 mu g/kg for all treatments in which it was included. Sedation was subjectively assessed and recorded on a visual analogue scale. Peak sedation, duration of sedation and the area under the curve (AUC) for sedation scores were investigated using a univariate general linear model with post-hoc Tukey tests (P<0.05). Peak sedation and duration of sedation were statistically significantly different between treatments (P<0.001). No sedation was apparent after administration of S/S. The AUC was significantly different between treatments (P=0.010), with S/S being significantly different from D/S, D/BUT, D/B5 and D/B7.5, but not D/B10 (P=0.051).

• 出版日期2011-4-9