Asymmetric Hydrogenation of Nonaromatic Cyclic Substrates

作者：Zhang, Zhenfeng; Butt, Nicholas A; Zhang, Wanbin^*

来源：Chemical Reviews, 2016, 116(23): 14769-14827.

DOI：10.1021/acs.chemrev.6b00564

• Asymmetric hydrogenation
• Chiral heterocycles
• Cyclic structures
• Cyclic substrates
• Environmentally benign
• Natural products
• Pharmaceutical compounds
• Synthetic intermediates

Chiral cyclic structures are found in numerous natural products, pharmaceutical compounds, and important synthetic intermediates. Asymmetric hydrogenation, allowing for the preparation of these complex targets in an environmentally benign and efficient manner, has received much attention over the past few years. This review summarizes the advances in the construction of chiral heterocycles and carbocycles (including cyclic amines, ethers, alcohols, and alkanes) via the asymmetric hydrogenation of nonaromatic cyclic substrates (including pro chiral cyclic imines, ketones, and alkenes) using appropriate transition-metal complexes.

• 出版日期2016-12-14
• 单位上海交通大学