Aphanamenes A and B, Two New Acyclic Diterpene [4+2]-Cycloaddition Adducts from Aphanamixis grandifolia

作者：Zhang, Hong-Jian; Luo, Jun; Shan, Si-Ming; Wang, Xiao-Bing; Luo, Jian-Guang; Yang, Ming-Hua; Kong, Ling-Yi^*

来源：Organic Letters, 2013, 15(21): 5512-5515.

DOI：10.1021/ol402516p

• LIMONOIDS
• CHEMISTRY
• FRUITS
• RING

Aphanamenes A (1) and B (2), two unprecedented acyclic diterpene dimers formed via a [4 + 2]-cycloaddition, were isolated from the root bark of Aphanamixis grandifolia. Their structures were elucidated by spectroscopic analyses, and the absolute configuration of 1 was determined by ECD calculations. Both 1 and 2 showed significant inhibition on NO production on lipopolysaccharide-induced RAW264.7 macrophages.

• 出版日期2013-11-1
• 单位中国药科大学; 天然药物活性组分与药效国家重点实验室